"Computational biology"

Cell-specific prediction and application of drug-induced gene expression profiles

Gene expression profiling of in vitro drug perturbations is useful for many biomedical discovery applications including drug repurposing and elucidation of drug mechanisms. However, limited data availability across cell types has hindered our …

Probabilistic Modeling of Systematic Errors in Two-Hybrid Experiments

We describe a novel probabilistic approach to estimating errors in two-hybrid (2H) experiments. Such experiments are frequently used to elucidate protein-protein interaction networks in a high-throughput fashion; however, a significant challenge with …